BPH Treatment Options

Treatment Goal	Medications^1–5	UroLift^® System Procedure^6–11	Water Vapor Therapy^12–15	Laser/TURP^1,16–18
Minimally invasive treatment that addresses prostate blockage	N/A	Reduces blockage. Can be performed in a doctor's office with local anesthesia	Reduces blockage. Can be performed in a doctor's office with local anesthesia	Reduces blockage. Typically done in a hospital or surgery center with increased anesthesia
Quick recovery^a	N/A	88–100% reported little or no interference at ~1 month	50–60% reported little or no interference at ~1 month	DATA NOT AVAILABLE
Minimal catheter use after procedure^b	N/A	10–32% catheter rate^c	75–100% catheter rate	~100% catheter rate
Low risk of serious complications	Floppy iris syndrome Depression & self-harm	3–7% urinary infection <1% urethral scarring 0–2% bleeding^d <1% bladder stones^e	7–17% urinary infection 0–4% urethral scarring 0–1% bleeding^d	10–20% urinary infection 3–7% urethral scarring 2–6% bleeding^d 0–2% urine leakage^f 0–1% TUR syndrome
Sexual preservation	3–5% erectile dysfunction, 1–10% ejaculatory dysfunction	0% erectile dysfunction, 0% ejaculatory dysfunction^g	0% erectile dysfunction, 3–20% ejaculatory dysfunction	7–10% erectile dysfunction, 40–60% ejaculatory dysfunction
One-time treatment without ongoing side effects	Daily requirement to take medications with associated side effects such as headaches, dizziness, lack of energy, insomnia and nasal congestion while on treatment	Typically, a one-time procedure with associated side effects such as temporary blood in urine and pain	Typically, a one-time procedure with associated side effects such as temporary blood in urine and pain	Typically, a one-time procedure with associated side effects such as temporary blood in urine and pain
Significant symptom relief	4–7pt IPSS at 12 mo	10–11pt IPSS at 12 mo	10–11pt IPSS at 12 mo	~15pt IPSS at 12 mo
Long-lasting relief	Daily pill needed	2–3% per year retreatment	1–2% per year retreatment	1–2% per year retreatment

Minimally invasive treatment that addresses prostate blockage

Medications^1–5

N/A

UroLift^® System^6–11

Reduces blockage. Can be performed in a doctor's office with local anesthesia

Water Vapor Therapy^12–15

Reduces blockage. Can be performed in a doctor's office with local anesthesia

Laser/TURP^1,16–18

Reduces blockage. Typically done in a hospital or surgery center with increased anesthesia

Quick recovery^a

Medications^1–5

N/A

UroLift^® System^6–11

88–100% reported little or no interference at ~1 month

Water Vapor Therapy^12–15

50–60% reported little or no interference at ~1 month

Laser/TURP^1,16–18

DATA NOT
AVAILABLE

Minimal catheter use after procedure^b

Medications^1–5

N/A

UroLift^® System^6–11

10–32% catheter rate^c

Water Vapor Therapy^12–15

75–100% catheter rate

Laser/TURP^1,16–18

~100% catheter rate

Low risk of serious complications

Medications^1–5

Floppy iris syndrome
Depression & self-harm

UroLift^® System^6–11

3–7% urinary infection <1% urethral scarring, 0–2% bleeding^d, <1% bladder stones^e

Water Vapor Therapy^12–15

7–17% urinary infection, 0–4% urethral scarring, 0–1% bleeding^d

Laser/TURP^1,16–18

10–20% urinary infection, 3–7% urethral scarring, 2–6% bleeding^d, 0–2% urine leakage^f, 0–1% TUR syndrome

Sexual preservation^g

Medications^1–5

3–5% erectile dysfunction, 1–10% ejaculatory dysfunction

UroLift^® System^6–11

0% erectile dysfunction, 0% ejaculatory dysfunction^g

Water Vapor Therapy^12–15

0% erectile dysfunction, 3–20% ejaculatory dysfunction

Laser/TURP^1,16–18

7–10% erectile dysfunction, 40–60% ejaculatory dysfunction

One-time treatment without ongoing side effects

Medications^1–5

Daily requirement to take medications with associated side effects such as headaches, dizziness, lack of energy, insomnia and nasal congestion while on treatment

UroLift^® System^6–11

Typically, a one-time procedure with associated side effects such as temporary blood in urine and pain

Water Vapor Therapy^12–15

Typically, a one-time procedure with associated side effects such as temporary blood in urine and pain

Laser/TURP^1,16–18

Typically, a one-time procedure with associated side effects such as temporary blood in urine and pain

Significant symptom relief

Medications^1–5

4–7pt IPSS at 12 mo

UroLift^® System^6–11

10–11pt IPSS at 12 mo

Water Vapor Therapy^12–15

10–11pt IPSS at 12 mo

Laser/TURP^1,16–18

~15pt IPSS at 12 mo

Long-lasting relief

Medications^1–5

Daily pill needed

UroLift^™ System (PUL)^6–11

2–3% per year retreatment

Water Vapor Therapy (Rezūm)^12–15

1–2% per year retreatment

Laser/TURP^1,16–18

1–2% per year retreatment

Note: Data in the above table come from head-to-head studies between individual therapies as well as meta-analysis across multiple studies. Some studies were sponsored by Teleflex Incorporated, manufacturer of the UroLift^™ System. A comprehensive head-to-head study comparing all of the above therapies has not been conducted at this time.

Medications

These include alpha blockers, which relax bladder neck muscles, and 5-alpha reductase inhibitors which act to shrink the prostate.

UroLift™ System

Small implants are placed to lift or hold excess tissue out of the way so it no longer blocks the urethra – with no heating, cutting, or removal, of prostate tissue.^3,4

Thermotherapies

Heat, such as steam or hot water, is applied directly to the prostate to destroy excess tissue.

Laser

Concentrated light is used to generate precise, intense heat to destroy excess prostate tissue.

Waterjet Ablation

A high-velocity waterjet is used to destroy excess prostate tissue, using an image-guided robotic arm.

Transurethral Resection (TURP)

An electric wire loop or laser fiber is used to remove or vaporize excess prostate tissue.

Least Invasive Most Invasive

Don't Hesitate to Ask Your Doctor

Many people aren’t comfortable talking about sensitive health topics, even with their doctor, and may downplay or avoid discussing their worsening urinary issues. Health care professionals, especially urologists, often talk with people about urinary problems, and the good news is, BPH symptoms are generally treatable. Discussing your health concerns is the first step towards finding solutions.

Don't hesitate to ask your doctor about minimally invasive procedures like the UroLift™ System.

You May Need to Ask

Let your doctor know if BPH medications aren't helping enough or if you have concerns about potential side effects. Ask about minimally invasive treatment options that align with your treatment goals.

75%

Surveyed said they weren't informed about minimally invasive procedures as an alternative to BPH medications*

Take Care of #1

Part of the standard of care,⁶ the UroLift™ System can be used to treat a broad spectrum of anatomies, including lateral and obstructive median lobe and prostates up to 100cc.^4,5

#1

The UroLift™ System is the #1 chosen minimally invasive BPH procedure in the U.S.**

Don't Let BPH Hurt Your Sex Life

Patients treated with the UroLift™ System achieved better reported outcomes in sexual function^§ and satisfaction than men who received BPH medication.³

57%

Of men surveyed believe that BPH affects their relationships and 61% say it impacts sex*

For procedures

How fast will I experience BPH symptom relief?

What level of symptom relief can I expect?

What are the common side effects?

What are the anesthesia options; is a hospital stay required?

Would I go home with a catheter?

When can I return to normal activity?

For medications

What level of symptom relief can I expect?

What side effects are typical and are any serious?

Will I always need to be on BPH medications and are they known to be effective over time?

Will delaying having a procedure increase my risk of bladder or kidney disease?

If medications aren't helping enough, what are my options?

References

1. Roehrborn, J Urology 2013
2. AUA Guidelines 2003, 2020
3. Roehrborn, Eur Urol Focus 2021
4. Rukstalis, Prostate Cancer Prostatic Dis 2018
4. UroLift System Instructions for Use
5. AUA BPH Guidelines, 2021
† As with any medical procedure, individual results may vary. See patient safety for more information.
*Survey of US men aged 40+ who have been diagnosed with BPH (enlarged prostate) and are/have been treated with BPH medications, conducted by Teleflex in 2020. Data on file, n=96.
**U.S. 2022 estimates based on US Market Model 2022-24 (5-17-22 FINAL), which is in part based on Symphony Health PatientSource® 2018-21, as is and with no representations / warranties, including accuracy or completeness.
§ Based on an indirect comparison of erectile and ejaculatory function and sexual satisfaction in men who received PUL in controlled studies or in men who received medical therapy in the MTOPS study.

MAC11000-02 Rev A

Enlarged Prostate Treatment Options

How BPH Treatment Options Stack Up

References

What are my options?

Medications

UroLift™ System

Thermotherapies

Laser

Waterjet Ablation

Transurethral Resection (TURP)

Don't Hesitate to Ask Your Doctor

75%

#1

57%

Questions to Ask

For procedures

For medications

How long do UroLift results typically last?

Is the UroLift procedure permanent, and can the implants be removed if needed?

How does the UroLift System treatment compare to other treatment options?

References