New Data Analysis About PUL Outcomes for Obstructive Median Lobe

In September 2022, the Journal of Endourology published an article titled Prostatic Urethral Lift for Obstructive Median Lobes: Consistent Results Across Controlled Trial and Real-World Settings authored by Drs. Gregg Eure, Daniel Rukstalis and Claus Roehrborn¹. The article concludes that men with obstructive median lobes (OML) treated with PUL experience symptom improvement sooner and are satisfied more quickly compared to those treated with TURP, and have fewer post-op catheterizations. Please click here to find the press release recently issued by Teleflex.

Methodology

The analysis included patients across 3 controlled and 1 real world retrospective study. Specifically, outcomes of OML patients treated with PUL in controlled (the MedLift study, n=45) and real-world settings (i.e., the real-world retrospective study of PUL, n=180) were evaluated against comparator groups (subjects treated with TURP [n=36] and sham [n=66] in randomized controlled trials) to assess consistency in safety, symptom response and patient experience.

Key Findings

• MedLift study subjects experienced 170% greater symptom improvement at 3 months post-procedure to sham subjects in the L.I.F.T. study.
  
  
• MedLift study subjects had significantly greater improvement at 1 and 3 months, and similar improvement at 6 and 12 months to TURP subjects in the BPH6 trial.
  
  
• Significantly more MedLift subjects were satisfied sooner after treatment,while a similar rate of patient satisfaction was observed between MedLift and TURP subjects at 6 and 12 months post-treatment.
  
  
• Symptom improvement was equivalent among MedLift study subjects and the filtered real-world OML group at 3, 6, and 12 months post-treatment.
  
  
• Patients treated in a real-world setting experienced fewer post-op catheterizations without elevated adverse events as compared to the MedLift cohort.
   

Click to view OML procedure video, courtesy of Gregg Eure, MD

Results may vary

Conclusion

Although not as common as lateral lobe hyperplasia, median lobe obstruction is estimated to occur in up to 20% of men diagnosed with BPH and studies have shown that it can pose an increased risk for progression of clinical BPH and bladder outlet obstruction^2,3. Patients with obstructive median lobes are most often treated with watchful waiting, medications or invasive surgical interventions; however, there is another option! The article adds to the growing evidence in support of the Prostatic Urethral Lift (PUL) procedure with the UroLift^® System in treating lower urinary symptoms/BPH in men with OML.

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